Programme
CRISPR 2021
June 1-10, 2021
              

 

 
Tuesday, June 1, 2021
Session 1
4.00 pm-8.00 pm (GMT+2)
 
 
0
4.00 pm (GMT+2)

Opening remarks

 
0
4.15 pm (GMT+2)

Keynote: Spacer acquisition: scavenging for dead DNA to collect infection souvenirs

Luciano Marraffini
Rockefeller University, United States
0
5.00 pm (GMT+2)

A flexible seed in type III CRISPR-Cas allows for within-host spacer diversity

J. Steens
1Wageningen University, Wageningen, The Netherland
0
5.20 pm (GMT+2)

Break

 
0
5.30 pm (GMT+2)

The arm race in Streptococcus thermophilus,
the ups and downs of CRISPR-Cas systems

Sylvain Moineau
Université Laval, Canada
0
6.00 pm (GMT+2)

Regulation of CRISPR-Cas9 systems by natural single-guide RNAs

R. Workman, J. Modell
Molecular Biology & Genetics, Johns Hopkins School of Medicine, Baltimore, United States
0
6.20 pm (GMT+2)

Break

 
0
6.30 pm (GMT+2)

Heritable Human Genome Editing: Science, Ethics and the Art of Policymaking

Francoise Baylis
Dalhousie University, Canada
0
7.00 pm (GMT+2)

Panel discussion

F. Baylis, K. Davis, W. Isaacson, C. Zimmer
Wednesday, June 2, 2021
Session 2
4.00 pm-8.00 pm (GMT+2)
 
 
0
4.00 pm (GMT+2)

Structure and dynamics of CRISPR in natural populations

Rachel Whitaker
University of Illinois Urbana-Champaign, United States
0
4.30 pm (GMT+2)

Unique features of CRISPR spacer acquisition by the Type III-A system of Streptococcus thermophilus

S. Garrett
Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, United States
0
4.50 pm (GMT+2)

Break

 
0
5.00 pm (GMT+2)

Vagaries of CRISPR evolution: crossing the boundary between classes and moonlighting as regulators

Eugene Koonin
National Center for Biotechnology Information, NIH, United States
0
5.30 pm (GMT+2)

Introducing Cas-beta: a new family of compact class 2 CRISPR associated nucleases

G. Gasiunas
CasZyme, Vilnius, Lithuania 
0
5.50 pm (GMT+2)

Break

 
0
6.00 pm (GMT+2)

Roseburia intestinalis resistance to phage predation by CRISPR spacer acquisition in the mouse gut

Marianne De-Paepe
INRA, France
0
6.30 pm (GMT+2)

Positioning type IV structures and functions within class 1 CRISPR Cas systems

R. Jackson
Jackson Lab, Utah State University, Logan, United States
0
6.50 pm (GMT+2)

Break

 
0
7.00 pm (GMT+2)
Short-talks / Posters
 
Thursday, June 3, 2021
Session 3
10.00 am-2.00 pm (GMT+2)
 
 
0
10.00 am (GMT+2)

Characterization of natural and engineered Cas12 variants

John van der Oost
Wageningen University, The Netherlands
0
10.30 am (GMT+2)

A membrane-associated DHH-DHHA1 nuclease degrades type III CRISPR second messenger

W. Han
Huazhong Agricultural University, Wuhan, China
0
10.50 am (GMT+2)

Break

 
0
11.00 am (GMT+2)

TBD

Virgis Siksnys
Vilnius University, Lithuania
0
11.30 am (GMT+2)

Mapping metabolite – transcription factor interactions at a genome-scale using CRISPRi knockdown library screenings

M. Kuntz
Bacterial Metabolomics, CMFI - IMIT University Tübingen, Tübingen, Germany, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany
0
11.50 am (GMT+2)

Break

 
0
12.00 pm (GMT+2)

Sequence-specific toxicity of dCas9 in bacteria

T. Grébert
Synthetic Biology Group, Microbiology Department, Institut Pasteur, Paris, France
0
12.20 pm (GMT+2)

A gate and clamp regulate sequential DNA strand cleavage by CRISPR-Cas12a

M. Szczelkun
Biochemistry, University of Bristol, Bristol, United Kingdom
0
12.40 pm (GMT+2)

Short-talks / Posters

 
Friday, June 4, 2021
Session 4
4.00 pm-8.00 pm (GMT+2)
 
 
0
4.00 pm (GMT+2)

Exploration of Biological Diversity

Feng Zhang
Broad Institute of MIT and Harvard, Cambridge, United States
0
4.30 pm (GMT+2)

Development and Application of Minimal-PAM CRISPR-Cas Enzymes

B. Kleinstiver
Mass General Hospital and Harvard Medical School, Boston, United States
0
4.50 pm (GMT+2)

Break

 
0
5.00 pm (GMT+2)

Phase-dependent CRISPR evolution

Blake Wiedenheft
Montana State University, United States
0
5.30 pm (GMT+2)

The High-resolution Mechanism for Cas4-assisted PAM-selection and directional spacer acquisition in CRISPR-Cas

A. Ke
Department of Molecular Biology and Genetics, Cornell University, Ithaca, United States
0
5.50 pm (GMT+2)

Break

 
0
6.00 pm (GMT+2)

Mechanisms of host-pathogen co-evolution in CRISPR-Cas immunity

Dipali Sashital
Iowa State University, United States
0
6.30 pm (GMT+2)

Targeted DNA Editing Within Microbial Communities

B. Rubin, B. Cress
Innovative Genomics Institute, UC Berkeley, Berkeley, United States
0
6.50 pm (GMT+2)

Break

 
0
7.00 pm (GMT+2)

Free slot / Spatial chat networking

 
Monday, June 7, 2021
Session 5
4.00 pm-8.00 pm (GMT+2)
 
 
0
4.00 pm (GMT+2)

Functional Interplay Between CRISPR-Cas and Transposable Elements

Samuel Sternberg
Columbia University, United States
0
4.30 pm (GMT+2)

Harnessing diverse compact CRISPR-Cas3 for long-range genome engineering

Y. Zhang
Dept of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Mi, United States
0
4.50 pm (GMT+2)

Break

 
0
5.00 pm (GMT+2)

Complex CRISPR-Cas and anti-CRISPR interactions in archaeon Sulfolobus

Xu Peng
University of Copenhagen, Denmark
0
5.30 pm (GMT+2)

Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells

P. Donohoue
Caribou Biosciences, Berkeley, United States
0
5.50 pm (GMT+2)

Break

 
0
6.00 pm (GMT+2)

Expanding the functional repertoire of CRISPR gene editing

David A. Scott
Arbor Biotechnologies, United States
0
6.30 pm (GMT+2)

Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics

P. Arantes
Bioengineering, University California, Riverside, Riverside, United States
0
6.50 pm (GMT+2)

Break

 
0
7.00 pm (GMT+2)

Career Panel

 
Tuesday, June 8, 2021
Session 6
4.00 pm-8.00 pm (GMT+2)
 
 
0
4.00 pm (GMT+2)

An anti-CRISPR that Rips Apart the Type I-F CRISPR-Cas System

Alan Davidson
University of Toronto, Canada
0
4.30 pm (GMT+2)

Anti-CRISPR Proteins are Associated with Ribbon-Helix-Helix DNA-binding Domains

C. Trost
Department of Molecular Genetics, University of Toronto, Toronto, Canada
0
4.50 pm (GMT+2)

Break

 
0
5.00 pm (GMT+2)

Impact of anti-CRISPR on the ecology and evolution of phages and bacteria

Anne Chevallereau
CNRS, France
0
5.30 pm (GMT+2)

Single Cell Variability of CRISPR-Cas Interference and Adaptation

R. Mckenzie
Department of Bionanoscience, Delft University of Technology, Delft, The Netherlands, AMOLF, Amsterdam, The Netherlands
0
5.50 pm (GMT+2)

Break

 
0
6.00 pm (GMT+2)

tRNA cleavage by Cas13a protein from Leptotrichia shahii

E. Semenova
Waksman Institute, Rutgers University, Piscataway, United States
0
6.20 pm (GMT+2)

AcrVA2 inhibits Cas12a biogenesis via translation-dependent mRNA degradation

N. Marino
Microbiology and Immunology, Bondy-Denomy Lab, University of California San Francisco, San Francisco, United States
0
6.40 pm (GMT+2)
Short-talks / Posters
 
Wednesday, June 9, 2021
Session 7
10.00 am-2.00 pm (GMT+2)
 
 
0
10.00 am (GMT+2)

Non-canonical crRNAs derived from host transcripts enable multiplexable RNA detection

Cynthia Sharma
Wuerzburg University, IMIB, Germany
0
10.30 am (GMT+2)

Bacteriostatic antibiotics promote the evolution of CRISPR-Cas immunity against phage in a human pathogen

T. Dimitriu
University of Exeter, Penryn, United Kingdom
0
10.50 am (GMT+2)

Break

 
0
11.00 am (GMT+2)

So, who's defending whom from what?

Eduardo Rocha
Institut Pasteur, France
0
11.30 am (GMT+2)

CRISPR-Cas is associated with fewer AMR genes in bacterial human pathogens

E. Pursey
University of Exeter, Penryn, United Kingdom
0
11.50 am (GMT+2)

Break

 
0
12.00 pm (GMT+2)

New insights from CRISPR spacer mapping

Stan Brouns
TU Delft, The Netherlands
0
12.30 pm (GMT+2)

Cas13 immune defense and autoimmunity is dictated by a threshold for RNA target levels

E. Vialetto
Helmholtz Institut for RNA-based infection research (HIRI), Würzburg, Germany
0
12.50 pm (GMT+2)

Break

 
0
1.00 pm (GMT+2)
Short-talks / Posters
 
Thursday, June 10, 2021
Session 8
4.00 pm-7.00 pm (GMT+2)
 
 
0
4.00 pm (GMT+2)

New genetic systems that protect bacteria from phage

Rotem Sorek
Weizmann Institute of Science, Israel
0
4.30 pm (GMT+2)

Antiviral activity of bacterial TIR domains via signaling molecules that trigger cell death

G. Ofir
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
0
4.50 pm (GMT+2)

Break

 
0
5.00 pm (GMT+2)

Quorum sensing anti-activation in the phage-host evolutionary arms race

Karen Maxwell
University of Toronto, Canada
0
5.30 pm (GMT+2)

Characterizing a novel anti-phage immune system in Staphylococcus epidermidis

N. Bari
Microbiology, University of Illinois at Urbana-Champaign, Urbana, United States
0
5.50 pm (GMT+2)

Break

 
0
6.00 pm (GMT+2)

Multiplexed genome editing of poplar for improved fiber processing and sustainable forestry

J. Wang
TreeCo, NC State University, Raleigh, United States, North Carolina State University, Raleigh, United States, Northeast Forestry University, Harbin, China
0
6.20 pm (GMT+2)

New mechanisms and applications of CRISPR-Cas systems

Jennifer Doudna
UC Berkeley, United States
0
6.50 pm (GMT+2)

Closing remarks

 

 

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